LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injur...
LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury
About this item
Full title
Author / Creator
Nakamura, Shuhei , Shigeyama, Saki , Minami, Satoshi , Shima, Takayuki , Akayama, Shiori , Matsuda, Tomoki , Esposito, Alessandra , Napolitano, Gennaro , Kuma, Akiko , Namba-Hamano, Tomoko , Nakamura, Jun , Yamamoto, Kenichi , Sasai, Miwa , Tokumura, Ayaka , Miyamoto, Mika , Oe, Yukako , Fujita, Toshiharu , Terawaki, Seigo , Takahashi, Atsushi , Hamasaki, Maho , Yamamoto, Masahiro , Okada, Yukinori , Komatsu, Masaaki , Nagai, Takeharu , Takabatake, Yoshitsugu , Xu, Haoxing , Isaka, Yoshitaka , Ballabio, Andrea and Yoshimori, Tamotsu
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Sensing and clearance of dysfunctional lysosomes is critical for cellular homeostasis. Here we show that transcription factor EB (TFEB)—a master transcriptional regulator of lysosomal biogenesis and autophagy—is activated during the lysosomal damage response, and its activation is dependent on the function of the ATG conjugation system, which media...
Alternative Titles
Full title
LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury
Authors, Artists and Contributors
Author / Creator
Shigeyama, Saki
Minami, Satoshi
Shima, Takayuki
Akayama, Shiori
Matsuda, Tomoki
Esposito, Alessandra
Napolitano, Gennaro
Kuma, Akiko
Namba-Hamano, Tomoko
Nakamura, Jun
Yamamoto, Kenichi
Sasai, Miwa
Tokumura, Ayaka
Miyamoto, Mika
Oe, Yukako
Fujita, Toshiharu
Terawaki, Seigo
Takahashi, Atsushi
Hamasaki, Maho
Yamamoto, Masahiro
Okada, Yukinori
Komatsu, Masaaki
Nagai, Takeharu
Takabatake, Yoshitsugu
Xu, Haoxing
Isaka, Yoshitaka
Ballabio, Andrea
Yoshimori, Tamotsu
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2447311720
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2447311720
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-020-00583-9
