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A new lymphoid-primed progenitor marked by Dach1 downregulation identified with single cell multi-om...

A new lymphoid-primed progenitor marked by Dach1 downregulation identified with single cell multi-om...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2452500133

A new lymphoid-primed progenitor marked by Dach1 downregulation identified with single cell multi-omics

About this item

Full title

A new lymphoid-primed progenitor marked by Dach1 downregulation identified with single cell multi-omics

Publisher

New York: Nature Publishing Group US

Journal title

Nature immunology, 2020-12, Vol.21 (12), p.1574-1584

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

A classical view of blood cell development is that multipotent hematopoietic stem and progenitor cells (HSPCs) become lineage-restricted at defined stages. Lin

c-Kit
+
Sca-1
+
Flt3
+
cells, termed lymphoid-primed multipotent progenitors (LMPPs), have lost megakaryocyte and erythroid potential but are heterogeneous in their...

Alternative Titles

Full title

A new lymphoid-primed progenitor marked by Dach1 downregulation identified with single cell multi-omics

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2452500133

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2452500133

Other Identifiers

ISSN

1529-2908

E-ISSN

1529-2916

DOI

10.1038/s41590-020-0799-x

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