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Utility of methylthioadenosine phosphorylase immunohistochemical deficiency as a surrogate for CDKN2...

Utility of methylthioadenosine phosphorylase immunohistochemical deficiency as a surrogate for CDKN2...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2452500405

Utility of methylthioadenosine phosphorylase immunohistochemical deficiency as a surrogate for CDKN2A homozygous deletion in the assessment of adult-type infiltrating astrocytoma

About this item

Full title

Utility of methylthioadenosine phosphorylase immunohistochemical deficiency as a surrogate for CDKN2A homozygous deletion in the assessment of adult-type infiltrating astrocytoma

Publisher

New York: Elsevier Inc

Journal title

Modern pathology, 2021-04, Vol.34 (4), p.688-700

Language

English

Formats

Publication information

Publisher

New York: Elsevier Inc

More information

Scope and Contents

Contents

Homozygous deletion (HD) of CDKN2A is one of the most promising biomarkers for predicting poor prognosis of IDH-mutant diffuse gliomas. The Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (cIMPACT-NOW) recommendations propose that IDH-mutant lower-grade astrocytomas with CDKN2A/B HD be classified as grade IV tumors. Lo...

Alternative Titles

Full title

Utility of methylthioadenosine phosphorylase immunohistochemical deficiency as a surrogate for CDKN2A homozygous deletion in the assessment of adult-type infiltrating astrocytoma

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2452500405

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2452500405

Other Identifiers

ISSN

0893-3952

E-ISSN

1530-0285

DOI

10.1038/s41379-020-00701-w

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