Sirtuin-1 inhibits endothelin-2 expression in human granulosa-lutein cells via hypoxia inducible fac...
Sirtuin-1 inhibits endothelin-2 expression in human granulosa-lutein cells via hypoxia inducible factor 1 alpha and epigenetic modifications
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United States: Society for the Study of Reproduction
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English
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United States: Society for the Study of Reproduction
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Endothelin-2 (EDN2) expression in granulosa cells was previously shown to be highly dependent on the hypoxic mediator, hypoxia inducible factor 1 alpha (HIF1A). Here, we investigated whether sirtuin-1 (SIRT1), by deacetylating HIF1A and class III histones, modulates EDN2 in human granulosa-lutein cells (hGLCs). We found that HIF1A was markedly supp...
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Full title
Sirtuin-1 inhibits endothelin-2 expression in human granulosa-lutein cells via hypoxia inducible factor 1 alpha and epigenetic modifications
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TN_cdi_proquest_miscellaneous_2455172754
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2455172754
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ISSN
0006-3363
E-ISSN
1529-7268
DOI
10.1093/biolre/ioaa199
