Mevalonate Pathway-mediated ER Homeostasis Is Required for Haploid Stability in Human Somatic Cells
Mevalonate Pathway-mediated ER Homeostasis Is Required for Haploid Stability in Human Somatic Cells
About this item
Full title
Author / Creator
Publisher
Japan: Japan Society for Cell Biology
Journal title
Language
English
Formats
Publication information
Publisher
Japan: Japan Society for Cell Biology
Subjects
More information
Scope and Contents
Contents
The somatic haploidy is unstable in diplontic animals, but cellular processes determining haploid stability remain elusive. Here, we found that inhibition of mevalonate pathway by pitavastatin, a widely used cholesterol-lowering drug, drastically destabilized the haploid state in HAP1 cells. Interestingly, cholesterol supplementation did not restor...
Alternative Titles
Full title
Mevalonate Pathway-mediated ER Homeostasis Is Required for Haploid Stability in Human Somatic Cells
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2473399337
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2473399337
Other Identifiers
ISSN
0386-7196,1347-3700
E-ISSN
1347-3700
DOI
10.1247/csf.20055
