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Heregulin-induced cell migration is prevented by trastuzumab and trastuzumab-emtansine in HER2+ brea...

Heregulin-induced cell migration is prevented by trastuzumab and trastuzumab-emtansine in HER2+ brea...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2479736704

Heregulin-induced cell migration is prevented by trastuzumab and trastuzumab-emtansine in HER2+ breast cancer

About this item

Full title

Heregulin-induced cell migration is prevented by trastuzumab and trastuzumab-emtansine in HER2+ breast cancer

Publisher

New York: Springer US

Journal title

Breast cancer research and treatment, 2021-04, Vol.186 (2), p.363-377

Language

English

Formats

Publication information

Publisher

New York: Springer US

More information

Scope and Contents

Contents

Purpose
Heregulin (HRG) signaling has been implicated in the development of an aggressive phenotype in breast cancer (BC) cells, and HER2 overexpression has been associated with a worse prognosis in BC patients. Nevertheless, the molecular mechanisms through which HRG affects the efficiency of anti-HER2 therapies such as trastuzumab (Tz) and tra...

Alternative Titles

Full title

Heregulin-induced cell migration is prevented by trastuzumab and trastuzumab-emtansine in HER2+ breast cancer

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2479736704

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2479736704

Other Identifiers

ISSN

0167-6806,1573-7217

E-ISSN

1573-7217

DOI

10.1007/s10549-020-06089-0

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