Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex
Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Human serine palmitoyltransferase (SPT) complex catalyzes the initial and rate-limiting step in the de novo biosynthesis of all sphingolipids. ORMDLs regulate SPT function, with human ORMDL3 being related to asthma. Here we report three high-resolution cryo-EM structures: the human SPT complex, composed of SPTLC1, SPTLC2 and SPTssa; the SPT–ORMDL3...
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Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex
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TN_cdi_proquest_miscellaneous_2487750198
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2487750198
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-020-00553-7
