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Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behavi...

Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behavi...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2491942978

Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study

About this item

Full title

Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study

Publisher

England: Elsevier Ltd

Journal title

Lancet neurology, 2021-03, Vol.20 (3), p.203-212

Language

English

Formats

Publication information

Publisher

England: Elsevier Ltd

More information

Scope and Contents

Contents

Isolated rapid-eye-movement (REM) sleep behaviour disorder (IRBD) can be part of the prodromal stage of the α-synucleinopathies Parkinson's disease and dementia with Lewy bodies. Real-time quaking-induced conversion (RT-QuIC) analysis of CSF has high sensitivity and specificity for the detection of misfolded α-synuclein in patients with Parkinson's...

Alternative Titles

Full title

Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2491942978

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2491942978

Other Identifiers

ISSN

1474-4422

E-ISSN

1474-4465

DOI

10.1016/S1474-4422(20)30449-X

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