Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin
Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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The COVID-19 pandemic caused by nonstop infections of SARS-CoV-2 has continued to ravage many countries worldwide. Here we report that suramin, a 100-year-old drug, is a potent inhibitor of the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) and acts by blocking the binding of RNA to the enzyme. In biochemical assays, suramin and its derivatives are...
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Full title
Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin
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TN_cdi_proquest_miscellaneous_2498480187
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2498480187
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-021-00570-0
