Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activ...
Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR–STAT3 signalling
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Author / Creator
Gao, Xinya , Xia, Xin , Li, Fanying , Zhang, Maolei , Zhou, Huangkai , Wu, Xujia , Zhong, Jian , Zhao, Zheng , Zhao, Kun , Liu, Dawei , Xiao, Feizhe , Xu, Qiang , Jiang, Tao , Li, Bo , Cheng, Shi-Yuan and Zhang, Nu
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Activated EGFR signalling drives tumorigenicity in 50% of glioblastoma (GBM). However, EGFR-targeting therapy has proven ineffective in treating patients with GBM, indicating that there is redundant EGFR activation. Circular RNAs are covalently closed RNA transcripts that are involved in various physiological and pathological processes. Herein, we...
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Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR–STAT3 signalling
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TN_cdi_proquest_miscellaneous_2498491239
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2498491239
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-021-00639-4
