FOXP1 drives osteosarcoma development by repressing P21 and RB transcription downstream of P53
FOXP1 drives osteosarcoma development by repressing P21 and RB transcription downstream of P53
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Osteosarcoma has a poor prognosis, and the poor understanding of the genetic drivers of osteosarcoma hinders further improvement in therapeutic approaches. Transcription factor forkhead box P1 (FOXP1) is a crucial modulator in skeletal development and aging. Here, we determined the role and regulatory mechanisms of FOXP1 in osteosarcoma. Higher FOX...
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FOXP1 drives osteosarcoma development by repressing P21 and RB transcription downstream of P53
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TN_cdi_proquest_miscellaneous_2501482156
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2501482156
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-021-01742-4
