TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming
TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming
About this item
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Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Classic major histocompatibility complex class I (MHC-I) presentation relies on shuttling cytosolic peptides into the endoplasmic reticulum (ER) by the transporter associated with antigen processing (TAP). Viruses disable TAP to block MHC-I presentation and evade cytotoxic CD8
+
T cells. Priming CD8
+
T cells against these viruses is th...
Alternative Titles
Full title
TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming
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TN_cdi_proquest_miscellaneous_2507727983
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2507727983
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-021-00903-7
