CRISPR screens identify a novel combination treatment targeting BCL-XL and WNT signaling for KRAS/BR...
CRISPR screens identify a novel combination treatment targeting BCL-XL and WNT signaling for KRAS/BRAF-mutated colorectal cancers
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Metastatic or recurrent colorectal cancer (CRC) patients require systemic chemotherapy, but the therapeutic options of targeted agents remain limited. CRC patients with
KRAS
or
BRAF
gene mutations exhibit a worse prognosis and are resistant to anti-EGFR treatment. Previous studies have shown that the expression of anti-apoptotic protein...
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Full title
CRISPR screens identify a novel combination treatment targeting BCL-XL and WNT signaling for KRAS/BRAF-mutated colorectal cancers
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TN_cdi_proquest_miscellaneous_2512333751
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2512333751
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ISSN
0950-9232,1476-5594
E-ISSN
1476-5594
DOI
10.1038/s41388-021-01777-7
