A physiologically-based pharmacokinetic model to describe antisense oligonucleotide distribution aft...
A physiologically-based pharmacokinetic model to describe antisense oligonucleotide distribution after intrathecal administration
About this item
Full title
Author / Creator
Publisher
New York: Springer US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Springer US
Subjects
More information
Scope and Contents
Contents
Antisense oligonucleotides (ASOs) are promising therapeutic agents for a variety of neurodegenerative and neuromuscular disorders, e.g., Alzheimer’s, Parkinson’s and Huntington’s diseases, spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS), caused by genetic abnormalities or increased protein accumulation. The blood–brain barrier...
Alternative Titles
Full title
A physiologically-based pharmacokinetic model to describe antisense oligonucleotide distribution after intrathecal administration
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2528179458
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2528179458
Other Identifiers
ISSN
1567-567X
E-ISSN
1573-8744
DOI
10.1007/s10928-021-09761-0
