Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replicati...
Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress
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Author / Creator
Xu, Xinlin , Xu, Yixi , Guo, Ruiyuan , Xu, Ran , Fu, Congcong , Xing, Mengtan , Sasanuma, Hiroyuki , Li, Qing , Takata, Minoru , Takeda, Shunichi , Guo, Rong and Xu, Dongyi
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Fanconi anemia (FA) is a devastating hereditary disease characterized by bone marrow failure (BMF) and acute myeloid leukemia (AML). As FA-deficient cells are hypersensitive to DNA interstrand crosslinks (ICLs), ICLs are widely assumed to be the lesions responsible for FA symptoms. Here, we show that FA-mutated cells are hypersensitive to persisten...
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Full title
Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress
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TN_cdi_proquest_miscellaneous_2540514340
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2540514340
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-021-00602-9
