Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent pr...
Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility
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Author / Creator
Koester, Janis , Miroshnikova, Yekaterina A. , Ghatak, Sushmita , Chacón-Martínez, Carlos Andrés , Morgner, Jessica , Li, Xinping , Atanassov, Ilian , Altmüller, Janine , Birk, David E. , Koch, Manuel , Bloch, Wilhelm , Bartusel, Michaela , Niessen, Carien M. , Rada-Iglesias, Alvaro and Wickström, Sara A.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Tissue turnover requires activation and lineage commitment of tissue-resident stem cells (SCs). These processes are impacted by ageing, but the mechanisms remain unclear. Here, we addressed the mechanisms of ageing in murine hair follicle SCs (HFSCs) and observed a widespread reduction in chromatin accessibility in aged HFSCs, particularly at key s...
Alternative Titles
Full title
Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility
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Record Identifier
TN_cdi_proquest_miscellaneous_2550263461
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2550263461
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-021-00705-x
