Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity...
Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Driver mutations in genes encoding histone H3 proteins resulting in p.Lys27Met substitutions (H3-K27M) are frequent in pediatric midline brain tumors. However, the precise mechanisms by which H3-K27M causes tumor initiation remain unclear. Here, we use human hindbrain neural stem cells to model the consequences of H3.3-K27M on the epigenomic landsc...
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Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells
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TN_cdi_proquest_miscellaneous_2555109121
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2555109121
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-021-00897-w
