Age-related LRRK2 G2019S Mutation Impacts Microglial Dopaminergic Fiber Refinement and Synaptic Prun...
Age-related LRRK2 G2019S Mutation Impacts Microglial Dopaminergic Fiber Refinement and Synaptic Pruning Involved in Abnormal Behaviors
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Author / Creator
Zhang, Qiuyang , Cheng, Xiaojuan , Wu, Wei , Yang, Siyu , You, Hanlin , Ye, Zucheng , Liu, Nan , Chen, Xiaochun and Pan, Xiaodong
Publisher
New York: Springer US
Journal title
Language
English
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Publisher
New York: Springer US
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Contents
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most frequent cause of autosomal dominant Parkinson’s disease (PD), producing psychiatric and motor symptoms. We conducted this study to explore whether microglial dopaminergic (DAergic) fiber refinement and synaptic pruning are involved in the abnormal behavioral phenotypes of carr...
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Full title
Age-related LRRK2 G2019S Mutation Impacts Microglial Dopaminergic Fiber Refinement and Synaptic Pruning Involved in Abnormal Behaviors
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Record Identifier
TN_cdi_proquest_miscellaneous_2562833132
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2562833132
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ISSN
0895-8696
E-ISSN
1559-1166
DOI
10.1007/s12031-021-01896-6
