Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications...
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression
About this item
Full title
Author / Creator
Yun, Haiyang , Narayan, Nisha , Vohra, Shabana , Giotopoulos, George , Mupo, Annalisa , Madrigal, Pedro , Sasca, Daniel , Lara-Astiaso, David , Horton, Sarah J. , Agrawal-Singh, Shuchi , Meduri, Eshwar , Basheer, Faisal , Marando, Ludovica , Gozdecka, Malgorzata , Dovey, Oliver M. , Castillo-Venzor, Aracely , Wang, Xiaonan , Gallipoli, Paolo , Müller-Tidow, Carsten , Osborne, Cameron S. , Vassiliou, George S. and Huntly, Brian J. P.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Altered transcription is a cardinal feature of acute myeloid leukemia (AML); however, exactly how mutations synergize to remodel the epigenetic landscape and rewire three-dimensional DNA topology is unknown. Here, we apply an integrated genomic approach to a murine allelic series that models the two most common mutations in AML:
Flt3
-
ITD...
Alternative Titles
Full title
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression
Authors, Artists and Contributors
Author / Creator
Narayan, Nisha
Vohra, Shabana
Giotopoulos, George
Mupo, Annalisa
Madrigal, Pedro
Sasca, Daniel
Lara-Astiaso, David
Horton, Sarah J.
Agrawal-Singh, Shuchi
Meduri, Eshwar
Basheer, Faisal
Marando, Ludovica
Gozdecka, Malgorzata
Dovey, Oliver M.
Castillo-Venzor, Aracely
Wang, Xiaonan
Gallipoli, Paolo
Müller-Tidow, Carsten
Osborne, Cameron S.
Vassiliou, George S.
Huntly, Brian J. P.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2576650846
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2576650846
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-021-00925-9
