Dual-function enzyme catalysis for enantioselective carbon–nitrogen bond formation
Dual-function enzyme catalysis for enantioselective carbon–nitrogen bond formation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Chiral amines can be made by insertion of a carbene into an N–H bond using two-catalyst systems that combine a transition metal-based carbene-transfer catalyst and a chiral proton-transfer catalyst to enforce stereocontrol. Haem proteins can effect carbene N–H insertion, but asymmetric protonation in an active site replete with proton sources is ch...
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Dual-function enzyme catalysis for enantioselective carbon–nitrogen bond formation
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TN_cdi_proquest_miscellaneous_2583445297
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2583445297
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ISSN
1755-4330
E-ISSN
1755-4349
DOI
10.1038/s41557-021-00794-z
