Efficacy and safety of maralixibat treatment in patients with Alagille syndrome and cholestatic prur...
Efficacy and safety of maralixibat treatment in patients with Alagille syndrome and cholestatic pruritus (ICONIC): a randomised phase 2 study
About this item
Full title
Author / Creator
Gonzales, Emmanuel , Hardikar, Winita , Stormon, Michael , Baker, Alastair , Hierro, Loreto , Gliwicz, Dorota , Lacaille, Florence , Lachaux, Alain , Sturm, Ekkehard , Setchell, Kenneth D R , Kennedy, Ciara , Dorenbaum, Alejandro , Steinmetz, Jana , Desai, Nirav K , Wardle, Andrew J , Garner, Will , Vig, Pamela , Jaecklin, Thomas , Sokal, Etienne M and Jacquemin, Emmanuel
Publisher
England: Elsevier Ltd
Journal title
Language
English
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Publication information
Publisher
England: Elsevier Ltd
Subjects
More information
Scope and Contents
Contents
Alagille syndrome is a rare genetic disease that often presents with severe cholestasis and pruritus. There are no approved drugs for management. Maralixibat, an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid recirculation. We evaluated the safety and efficacy of maralixibat for children with cholestasis i...
Alternative Titles
Full title
Efficacy and safety of maralixibat treatment in patients with Alagille syndrome and cholestatic pruritus (ICONIC): a randomised phase 2 study
Authors, Artists and Contributors
Author / Creator
Hardikar, Winita
Stormon, Michael
Baker, Alastair
Hierro, Loreto
Gliwicz, Dorota
Lacaille, Florence
Lachaux, Alain
Sturm, Ekkehard
Setchell, Kenneth D R
Kennedy, Ciara
Dorenbaum, Alejandro
Steinmetz, Jana
Desai, Nirav K
Wardle, Andrew J
Garner, Will
Vig, Pamela
Jaecklin, Thomas
Sokal, Etienne M
Jacquemin, Emmanuel
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2596011993
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2596011993
Other Identifiers
ISSN
0140-6736
E-ISSN
1474-547X
DOI
10.1016/S0140-6736(21)01256-3
