Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps
Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps
About this item
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Author / Creator
Adeyemo, Adebowale , Balaconis, Mary K. , Darnes, Deanna R. , Fatumo, Segun , Granados Moreno, Palmira , Hodonsky, Chani J. , Inouye, Michael , Kanai, Masahiro , Kato, Kazuto , Knoppers, Bartha M. , Lewis, Anna C. F. , Martin, Alicia R. , McCarthy, Mark I. , Meyer, Michelle N. , Okada, Yukinori , Richards, J. Brent , Richter, Lucas , Ripatti, Samuli , Rotimi, Charles N. , Sanderson, Saskia C. , Sturm, Amy C. , Verdugo, Ricardo A. , Widen, Elisabeth , Willer, Cristen J. , Wojcik, Genevieve L. , Zhou, Alicia and Polygenic Risk Score Task Force of the International Common Disease Alliance
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Polygenic risk scores (PRSs) aggregate the many small effects of alleles across the human genome to estimate the risk of a disease or disease-related trait for an individual. The potential benefits of PRSs include cost-effective enhancement of primary disease prevention, more refined diagnoses and improved precision when prescribing medicines. Howe...
Alternative Titles
Full title
Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps
Authors, Artists and Contributors
Author / Creator
Balaconis, Mary K.
Darnes, Deanna R.
Fatumo, Segun
Granados Moreno, Palmira
Hodonsky, Chani J.
Inouye, Michael
Kanai, Masahiro
Kato, Kazuto
Knoppers, Bartha M.
Lewis, Anna C. F.
Martin, Alicia R.
McCarthy, Mark I.
Meyer, Michelle N.
Okada, Yukinori
Richards, J. Brent
Richter, Lucas
Ripatti, Samuli
Rotimi, Charles N.
Sanderson, Saskia C.
Sturm, Amy C.
Verdugo, Ricardo A.
Widen, Elisabeth
Willer, Cristen J.
Wojcik, Genevieve L.
Zhou, Alicia
Polygenic Risk Score Task Force of the International Common Disease Alliance
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2598080427
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2598080427
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-021-01549-6
