Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced soli...
Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced solid tumours (ASPEN-01): a first-in-human, open-label, multicentre, phase 1 dose-escalation and dose-expansion study
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Author / Creator
Lakhani, Nehal J, MD , Chow, Laura Q M, Prof , Gainor, Justin F, MD , LoRusso, Patricia, Prof , Lee, Keun-Wook, Prof , Chung, Hyun Cheol, Prof , Lee, Jeeyun, Prof , Bang, Yung-Jue, Prof , Hodi, Frank Stephen, Prof , Kim, Won Seog, Prof , Santana-Davila, Rafael, MD , Fanning, Philip, PhD , Squifflet, Pierre, MS , Jin, Feng, PhD , Kuo, Tracy C, PhD , Wan, Hong I, PhD , Pons, Jaume, PhD , Randolph, Sophia S, MD and Messersmith, Wells A, Prof
Publisher
England: Elsevier Ltd
Journal title
Language
English
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Publication information
Publisher
England: Elsevier Ltd
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Scope and Contents
Contents
SummaryBackgroundBoth innate and adaptive immune responses are important components of anticancer immunity. The CD47–SIRPα interaction could represent an important pathway used by tumour cells to evade immune surveillance. We aimed to evaluate the safety, pharmacokinetics, pharmacodynamics, and anticancer activity of evorpacept (also known as ALX14...
Alternative Titles
Full title
Evorpacept alone and in combination with pembrolizumab or trastuzumab in patients with advanced solid tumours (ASPEN-01): a first-in-human, open-label, multicentre, phase 1 dose-escalation and dose-expansion study
Authors, Artists and Contributors
Author / Creator
Chow, Laura Q M, Prof
Gainor, Justin F, MD
LoRusso, Patricia, Prof
Lee, Keun-Wook, Prof
Chung, Hyun Cheol, Prof
Lee, Jeeyun, Prof
Bang, Yung-Jue, Prof
Hodi, Frank Stephen, Prof
Kim, Won Seog, Prof
Santana-Davila, Rafael, MD
Fanning, Philip, PhD
Squifflet, Pierre, MS
Jin, Feng, PhD
Kuo, Tracy C, PhD
Wan, Hong I, PhD
Pons, Jaume, PhD
Randolph, Sophia S, MD
Messersmith, Wells A, Prof
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2599183109
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2599183109
Other Identifiers
ISSN
1470-2045
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(21)00584-2
