A tumour-resident Lgr5+ stem-cell-like pool drives the establishment and progression of advanced gas...
A tumour-resident Lgr5+ stem-cell-like pool drives the establishment and progression of advanced gastric cancers
About this item
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Author / Creator
Fatehullah, A. , Terakado, Y. , Sagiraju, S. , Tan, T. L. , Sheng, T. , Tan, S. H. , Murakami, K. , Swathi, Y. , Ang, N. , Rajarethinam, R. , Ming, T. , Tan, P. , Lee, B. and Barker, N.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Gastric cancer is among the most prevalent and deadliest of cancers globally. To derive mechanistic insight into the pathways governing this disease, we generated a
Claudin18-IRES-CreERT2
allele to selectively drive conditional dysregulation of the Wnt, Receptor Tyrosine Kinase and Trp53 pathways within the gastric epithelium. This resulted i...
Alternative Titles
Full title
A tumour-resident Lgr5+ stem-cell-like pool drives the establishment and progression of advanced gastric cancers
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Record Identifier
TN_cdi_proquest_miscellaneous_2606923182
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2606923182
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-021-00793-9
