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AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intrave...

AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intrave...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2608538803

AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset

About this item

Full title

AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset

Publisher

New York: Nature Publishing Group US

Journal title

Nature neuroscience, 2022-01, Vol.25 (1), p.106-115

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

Genetic intervention is increasingly being explored as a therapeutic option for debilitating disorders of the central nervous system. The safety and efficacy of gene therapies rely upon expressing a transgene in affected cells while minimizing off-target expression. Here we show organ-specific targeting of adeno-associated virus (AAV) capsids after...

Alternative Titles

Full title

AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2608538803

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2608538803

Other Identifiers

ISSN

1097-6256,1546-1726

E-ISSN

1546-1726

DOI

10.1038/s41593-021-00969-4

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