Applications of and considerations for using CRISPR–Cas9-mediated gene conversion systems in rodents
Applications of and considerations for using CRISPR–Cas9-mediated gene conversion systems in rodents
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Genetic elements that are inherited at super-Mendelian frequencies could be used in a ‘gene drive’ to spread an allele to high prevalence in a population with the goal of eliminating invasive species or disease vectors. We recently demonstrated that the gene conversion mechanism underlying a CRISPR–Cas9-mediated gene drive is feasible in mice. Alth...
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Applications of and considerations for using CRISPR–Cas9-mediated gene conversion systems in rodents
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TN_cdi_proquest_miscellaneous_2614240303
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2614240303
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ISSN
1754-2189
E-ISSN
1750-2799
DOI
10.1038/s41596-021-00646-7