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Applications of and considerations for using CRISPR–Cas9-mediated gene conversion systems in rodents

Applications of and considerations for using CRISPR–Cas9-mediated gene conversion systems in rodents

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2614240303

Applications of and considerations for using CRISPR–Cas9-mediated gene conversion systems in rodents

About this item

Full title

Applications of and considerations for using CRISPR–Cas9-mediated gene conversion systems in rodents

Publisher

London: Nature Publishing Group UK

Journal title

Nature protocols, 2022-01, Vol.17 (1), p.3-14

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Genetic elements that are inherited at super-Mendelian frequencies could be used in a ‘gene drive’ to spread an allele to high prevalence in a population with the goal of eliminating invasive species or disease vectors. We recently demonstrated that the gene conversion mechanism underlying a CRISPR–Cas9-mediated gene drive is feasible in mice. Alth...

Alternative Titles

Full title

Applications of and considerations for using CRISPR–Cas9-mediated gene conversion systems in rodents

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2614240303

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2614240303

Other Identifiers

ISSN

1754-2189

E-ISSN

1750-2799

DOI

10.1038/s41596-021-00646-7

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