Biochanin A Sensitizes Glioblastoma to Temozolomide by Inhibiting Autophagy
Biochanin A Sensitizes Glioblastoma to Temozolomide by Inhibiting Autophagy
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Author / Creator
Dong, Qiang , Wang, Degui , Li, Lanlan , Wang, Jie , Li, Qiao , Duan, Lei , Yin, Hang , Wang, Xiaoqing , Liu, Yang , Yuan, Guoqiang and Pan, Yawen
Publisher
New York: Springer US
Journal title
Language
English
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Publisher
New York: Springer US
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Scope and Contents
Contents
Resistance to temozolomide (TMZ) chemotherapy is the main reason for treatment failure in patients with glioblastoma (GBM). In the present study, we investigated biochanin A (BCA) a potent sensitizer of TMZ in GBM. We observed that BCA significantly enhanced cell sensitivity to TMZ in vitro and in vivo. Mechanistically, the specific chemosensitizin...
Alternative Titles
Full title
Biochanin A Sensitizes Glioblastoma to Temozolomide by Inhibiting Autophagy
Authors, Artists and Contributors
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Record Identifier
TN_cdi_proquest_miscellaneous_2616609683
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2616609683
Other Identifiers
ISSN
0893-7648
E-ISSN
1559-1182
DOI
10.1007/s12035-021-02674-6
