CLUSTER guide RNAs enable precise and efficient RNA editing with endogenous ADAR enzymes in vivo
CLUSTER guide RNAs enable precise and efficient RNA editing with endogenous ADAR enzymes in vivo
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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RNA base editing represents a promising alternative to genome editing. Recent approaches harness the endogenous RNA-editing enzyme adenosine deaminase acting on RNA (ADAR) to circumvent problems caused by ectopic expression of engineered editing enzymes, but suffer from sequence restriction, lack of efficiency and bystander editing. Here we present...
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CLUSTER guide RNAs enable precise and efficient RNA editing with endogenous ADAR enzymes in vivo
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TN_cdi_proquest_miscellaneous_2616611127
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2616611127
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ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/s41587-021-01105-0
