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Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory resp...

Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory resp...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2619216625

Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory response of pancreatic beta cells

About this item

Full title

Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory response of pancreatic beta cells

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Journal title

Diabetologia, 2022-04, Vol.65 (4), p.705-720

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

More information

Scope and Contents

Contents

Aims/hypothesis
Chronic exposure of pancreatic beta cells to high glucose and fatty acids has been proposed to induce glucolipotoxicity. However, contradictory results suggest adaptations of the beta cells, which might be instrumental for partial preservation of the secretory response. In this context, we delineated the expression pattern of gen...

Alternative Titles

Full title

Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory response of pancreatic beta cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2619216625

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2619216625

Other Identifiers

ISSN

0012-186X

E-ISSN

1432-0428

DOI

10.1007/s00125-021-05633-x

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