The design of TOPK inhibitors using structure-based pharmacophore modeling and molecular docking bas...
The design of TOPK inhibitors using structure-based pharmacophore modeling and molecular docking based on an MD-refined homology model
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Publisher
Cham: Springer International Publishing
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Language
English
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Cham: Springer International Publishing
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Contents
The TOPK enzyme (also known as PBK) is a serine-threonine protein kinase that is rarely detected in normal tissues yet is found to be overexpressed and activated in a variety of cancers such as lung, colorectal, breast, and esophageal cancer. Its prevalence in cancerous cells is associated with their poor prognosis and responsiveness to treatment....
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The design of TOPK inhibitors using structure-based pharmacophore modeling and molecular docking based on an MD-refined homology model
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TN_cdi_proquest_miscellaneous_2620087462
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2620087462
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ISSN
1381-1991
E-ISSN
1573-501X
DOI
10.1007/s11030-021-10361-w
