Pamiparib Induces Neurodevelopmental Defects and Cerebral Haemorrhage in Zebrafish Embryos via Inhib...
Pamiparib Induces Neurodevelopmental Defects and Cerebral Haemorrhage in Zebrafish Embryos via Inhibiting Notch Signalling
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Author / Creator
Yang, Dou , Liu, Fasheng , Wan, Mengqi , Liu, Jieping , Huang, Ling , Chen, Chao , Li, Xue , Zhang, Li , Ding, Xiaobing , Liao, Xinjun , Xiong, Guanghua , Lu, Huiqiang , Xiao, Juhua and Cao, Zigang
Publisher
New York: Springer US
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Language
English
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Publisher
New York: Springer US
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Contents
Pamiparib is a poly ADP-ribose polymerase (PARP) inhibitor used in clinical studies, which can penetrate the blood–brain barrier efficiently. At present, there are few studies on its effect on vertebrate neurodevelopment. In this study, we exposed zebrafish embryos to 1, 2 and 3 µM of Pamiparib from 6 to 72 h post-fertilisation (hpf). Results showe...
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Full title
Pamiparib Induces Neurodevelopmental Defects and Cerebral Haemorrhage in Zebrafish Embryos via Inhibiting Notch Signalling
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TN_cdi_proquest_miscellaneous_2704871326
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2704871326
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ISSN
0893-7648
E-ISSN
1559-1182
DOI
10.1007/s12035-022-02988-z
