Physiologically based pharmacokinetic modeling of ponatinib to describe drug–drug interactions in pa...
Physiologically based pharmacokinetic modeling of ponatinib to describe drug–drug interactions in patients with cancer
About this item
Full title
Author / Creator
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
Purpose
This study aimed to investigate the drug–drug interactions of ponatinib with strong, moderate, or weak CYP3A4 inhibitors/inducers by developing physiologically based pharmacokinetic (PBPK) models.
Methods
Simcyp
®
Ver 20.1 (Certara Inc., Sheffield, UK) was used to construct a PBPK model for ponatinib and to predict its intera...
Alternative Titles
Full title
Physiologically based pharmacokinetic modeling of ponatinib to describe drug–drug interactions in patients with cancer
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2705751452
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2705751452
Other Identifiers
ISSN
0344-5704
E-ISSN
1432-0843
DOI
10.1007/s00280-022-04466-8
