Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-...
Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial
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Author / Creator
Spinazzi, Eleonora F, MD , Argenziano, Michael G, BA , Upadhyayula, Pavan S, MD , Banu, Matei A, MD , Neira, Justin A, MD , Higgins, Dominique M O, MD , Wu, Peter B, MD , Pereira, Brianna, BA , Mahajan, Aayushi, MS , Humala, Nelson, BA , Al-Dalahmah, Osama, MD DPhil , Zhao, Wenting, PhD , Save, Akshay V, MD MS , Gill, Brian J A, MD , Boyett, Deborah M, MD MS , Marie, Tamara, BA , Furnari, Julia L, BS , Sudhakar, Tejaswi D, BA , Stopka, Sylwia A, PhD , Regan, Michael S, BS , Catania, Vanessa, BS , Good, Laura, RN , Zacharoulis, Stergios, MD , Behl, Meenu, MSE , Petridis, Petros, MD , Jambawalikar, Sachin, PhD , Mintz, Akiva, Prof , Lignelli, Angela, MD , Agar, Nathalie Y R, PhD , Sims, Peter A, PhD , Welch, Mary R, MD , Lassman, Andrew B, Prof , Iwamoto, Fabio M, MD , D’Amico, Randy S, MD , Grinband, Jack, PhD , Canoll, Peter, Prof and Bruce, Jeffrey N, Prof
Publisher
England: Elsevier Ltd
Journal title
Language
English
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Publisher
England: Elsevier Ltd
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Contents
SummaryBackgroundTopotecan is cytotoxic to glioma cells but is clinically ineffective because of drug delivery limitations. Systemic delivery is limited by toxicity and insufficient brain penetrance, and, to date, convection-enhanced delivery (CED) has been restricted to a single treatment of restricted duration. To address this problem, we enginee...
Alternative Titles
Full title
Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial
Authors, Artists and Contributors
Author / Creator
Argenziano, Michael G, BA
Upadhyayula, Pavan S, MD
Banu, Matei A, MD
Neira, Justin A, MD
Higgins, Dominique M O, MD
Wu, Peter B, MD
Pereira, Brianna, BA
Mahajan, Aayushi, MS
Humala, Nelson, BA
Al-Dalahmah, Osama, MD DPhil
Zhao, Wenting, PhD
Save, Akshay V, MD MS
Gill, Brian J A, MD
Boyett, Deborah M, MD MS
Marie, Tamara, BA
Furnari, Julia L, BS
Sudhakar, Tejaswi D, BA
Stopka, Sylwia A, PhD
Regan, Michael S, BS
Catania, Vanessa, BS
Good, Laura, RN
Zacharoulis, Stergios, MD
Behl, Meenu, MSE
Petridis, Petros, MD
Jambawalikar, Sachin, PhD
Mintz, Akiva, Prof
Lignelli, Angela, MD
Agar, Nathalie Y R, PhD
Sims, Peter A, PhD
Welch, Mary R, MD
Lassman, Andrew B, Prof
Iwamoto, Fabio M, MD
D’Amico, Randy S, MD
Grinband, Jack, PhD
Canoll, Peter, Prof
Bruce, Jeffrey N, Prof
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2725190808
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2725190808
Other Identifiers
ISSN
1470-2045,1474-5488
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(22)00599-X
