Synthesis and discovery of the first potent proteolysis targeting chimaera (PROTAC) degrader of AIMP...
Synthesis and discovery of the first potent proteolysis targeting chimaera (PROTAC) degrader of AIMP2-DX2 as a lung cancer drug
About this item
Full title
Author / Creator
Lee, BoRa , Kim, Dae Gyu , Lee, Aram , Kim, Young Mi , Cui, Lianji , Kim, Sunghoon and Choi, Inhee
Publisher
Abingdon: Taylor & Francis
Journal title
Language
English
Formats
Publication information
Publisher
Abingdon: Taylor & Francis
Subjects
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Scope and Contents
Contents
ARS-interacting multifunctional proteins 2 (AIMP2) is known to be a powerful tumour suppressor. However, the target AIMP2-DX2, AIMP2-lacking exon 2, is often detected in many cancer patients and cells. The predominant approach for targeting AIMP-DX2 has been attempted via small molecule mediated inhibition, but due to the lack of satisfactory activ...
Alternative Titles
Full title
Synthesis and discovery of the first potent proteolysis targeting chimaera (PROTAC) degrader of AIMP2-DX2 as a lung cancer drug
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2730319629
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2730319629
Other Identifiers
ISSN
1475-6366
E-ISSN
1475-6374
DOI
10.1080/14756366.2022.2135510
