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T cells specific for α-myosin drive immunotherapy-related myocarditis

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T cells specific for α-myosin drive immunotherapy-related myocarditis

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2737465988

T cells specific for α-myosin drive immunotherapy-related myocarditis

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Publisher

London: Nature Publishing Group UK

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Contents

Immune-related adverse events, particularly severe toxicities such as myocarditis, are major challenges to the utility of immune checkpoint inhibitors (ICIs) in anticancer therapy
1
. The pathogenesis of ICI-associated myocarditis (ICI-MC) is poorly understood.
Pdcd1
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Ctla4
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mice recapitulate clinicopathological features...

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Full title

T cells specific for α-myosin drive immunotherapy-related myocarditis

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Record Identifier

TN_cdi_proquest_miscellaneous_2737465988

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2737465988

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ISSN

0028-0836,1476-4687

E-ISSN

1476-4687

DOI

10.1038/s41586-022-05432-3

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