Structural basis of the acyl-transfer mechanism of human GPAT1
Structural basis of the acyl-transfer mechanism of human GPAT1
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Author / Creator
Johnson, Zachary Lee , Ammirati, Mark , Wasilko, David Jonathan , Chang, Jeanne S. , Noell, Stephen , Foley, Timothy L. , Yoon, Hyejin , Smith, Kathleen , Asano, Shoh , Hales, Katherine , Wan, Min , Yang, Qingyi , Piotrowski, Mary A. , Farley, Kathleen A. , Gilbert, Tamara , Aschenbrenner, Lisa M. , Fennell, Kimberly F. , Dutra, Jason K. , Xu, Mary , Guo, Chunyang , Varghese, Alison E. , Bellenger, Justin , Quinn, Alandra , am Ende, Christopher W. , West, Graham M. , Griffor, Matthew C. , Bennett, Donald , Calabrese, Matthew , Steppan, Claire M. , Han, Seungil and Wu, Huixian
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis. Hepatic expression of GPAT1 is linked to liver fat accumulation and the severity of nonalcoholic fatty liver diseases. Here we present the cryo-EM structures of human GPAT1 in substrate analog-bo...
Alternative Titles
Full title
Structural basis of the acyl-transfer mechanism of human GPAT1
Authors, Artists and Contributors
Author / Creator
Ammirati, Mark
Wasilko, David Jonathan
Chang, Jeanne S.
Noell, Stephen
Foley, Timothy L.
Yoon, Hyejin
Smith, Kathleen
Asano, Shoh
Hales, Katherine
Wan, Min
Yang, Qingyi
Piotrowski, Mary A.
Farley, Kathleen A.
Gilbert, Tamara
Aschenbrenner, Lisa M.
Fennell, Kimberly F.
Dutra, Jason K.
Xu, Mary
Guo, Chunyang
Varghese, Alison E.
Bellenger, Justin
Quinn, Alandra
am Ende, Christopher W.
West, Graham M.
Griffor, Matthew C.
Bennett, Donald
Calabrese, Matthew
Steppan, Claire M.
Han, Seungil
Wu, Huixian
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2755574430
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2755574430
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-022-00884-7
