T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control
T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Antigen-specific CD8
+
T cell accumulation in tumors is a prerequisite for effective immunotherapy, and yet the mechanisms of lymphocyte transit are not well defined. Here we show that tumor-associated lymphatic vessels control T cell exit from tumors via the chemokine CXCL12, and intratumoral antigen encounter tunes CXCR4 expression by effec...
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Full title
T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control
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TN_cdi_proquest_miscellaneous_2780762485
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2780762485
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-023-01443-y
