CDK13 phosphorylates the translation machinery and promotes tumorigenic protein synthesis
CDK13 phosphorylates the translation machinery and promotes tumorigenic protein synthesis
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Author / Creator
Wu, Chao , Xie, Ting , Guo, Ying , Wang, Donghai , Qiu, Min , Han, Ruyi , Qing, Guoliang , Liang, Kaiwei and Liu, Hudan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Cyclin-dependent kinase 13 (CDK13) has been suggested to phosphorylate RNA polymerase II and is involved in transcriptional activation. However, whether CDK13 catalyzes other protein substrates and how CDK13 contributes to tumorigenesis remain largely unclear. We here identify key translation machinery components, 4E-BP1 and eIF4B, as novel CDK13 s...
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Full title
CDK13 phosphorylates the translation machinery and promotes tumorigenic protein synthesis
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Record Identifier
TN_cdi_proquest_miscellaneous_2784835499
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2784835499
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-023-02653-2
