Improving the on-target activity of high-fidelity Cas9 editors by combining rational design and rand...
Improving the on-target activity of high-fidelity Cas9 editors by combining rational design and random mutagenesis
About this item
Full title
Author / Creator
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Subjects
More information
Scope and Contents
Contents
Genomic and post-genomic editors based on CRISPR/Cas systems are widely used in basic research and applied sciences, including human gene therapy. Most genome editing tools are based on the CRISPR/Cas9 type IIA system from
Streptococcus pyogenes
. Unfortunately, a number of drawbacks have hindered its application in therapeutic approaches, th...
Alternative Titles
Full title
Improving the on-target activity of high-fidelity Cas9 editors by combining rational design and random mutagenesis
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2786812606
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2786812606
Other Identifiers
ISSN
0175-7598
E-ISSN
1432-0614
DOI
10.1007/s00253-023-12469-5
