TnpB structure reveals minimal functional core of Cas12 nuclease family
TnpB structure reveals minimal functional core of Cas12 nuclease family
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
The widespread TnpB proteins of IS200/IS605 transposon family have recently emerged as the smallest RNA-guided nucleases capable of targeted genome editing in eukaryotic cells
1
,
2
. Bioinformatic analysis identified TnpB proteins as the likely predecessors of Cas12 nucleases
3
–
5
, which along with Cas9 are widely used fo...
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Full title
TnpB structure reveals minimal functional core of Cas12 nuclease family
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TN_cdi_proquest_miscellaneous_2797147778
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2797147778
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ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-023-05826-x
