Perturbations in beta-cell heterogeneity in the pathogenesis of type 2 diabetes
Perturbations in beta-cell heterogeneity in the pathogenesis of type 2 diabetes
About this item
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Using single-cell transcriptomics and functional assays, we identified various subsets of pancreatic beta cells. One subset, characterized by high levels of CD63, demonstrated enhanced glucose metabolism, mitochondrial activity, and glucose-induced insulin secretion, and the proportion of these beta cells was decreased in mouse models of type 2 dia...
Alternative Titles
Full title
Perturbations in beta-cell heterogeneity in the pathogenesis of type 2 diabetes
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Record Identifier
TN_cdi_proquest_miscellaneous_2801982948
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2801982948
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-023-01105-z
