MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation
MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation
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Full title
Author / Creator
Dai, Tong , Zhang, Lei , Ran, Yu , Zhang, Meirong , Yang, Bing , Lu, Huasong , Lin, Shixian , Zhang, Long and Zhou, Fangfang
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Mitochondrial antiviral signaling protein (MAVS) is an adapter that recruits and activates IRF3. However, the mechanisms underpinning the interplay between MAVS and IRF3 are largely unknown. Here we show that small ubiquitin-like modifier (SUMO)-specific protease 1 negatively regulates antiviral immunity by deSUMOylating MAVS. Upon virus infection,...
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Full title
MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation
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Record Identifier
TN_cdi_proquest_miscellaneous_2814529743
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2814529743
Other Identifiers
ISSN
1545-9993,1545-9985
E-ISSN
1545-9985
DOI
10.1038/s41594-023-00988-8
