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Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and dis...

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Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and dis...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2838251556

Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases

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New York: Nature Publishing Group US

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Contents

Genome-wide association studies (GWASs) are a valuable tool for understanding the biology of complex human traits and diseases, but associated variants rarely point directly to causal genes. In the present study, we introduce a new method, polygenic priority score (PoPS), that learns trait-relevant gene features, such as cell-type-specific expressi...

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Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases

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TN_cdi_proquest_miscellaneous_2838251556

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2838251556

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ISSN

1061-4036,1546-1718

E-ISSN

1546-1718

DOI

10.1038/s41588-023-01443-6

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