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Nuclear staining for pan-Trk by immunohistochemistry is highly specific for secretory carcinoma of b...

Nuclear staining for pan-Trk by immunohistochemistry is highly specific for secretory carcinoma of b...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2852631886

Nuclear staining for pan-Trk by immunohistochemistry is highly specific for secretory carcinoma of breast: pan-Trk in various subtypes of breast carcinoma

About this item

Full title

Nuclear staining for pan-Trk by immunohistochemistry is highly specific for secretory carcinoma of breast: pan-Trk in various subtypes of breast carcinoma

Publisher

England: BMJ Publishing Group Ltd and Association of Clinical Pathologists

Journal title

Journal of clinical pathology, 2024-11, Vol.77 (11), p.751-755

Language

English

Formats

Publication information

Publisher

England: BMJ Publishing Group Ltd and Association of Clinical Pathologists

More information

Scope and Contents

Contents

AimsSecretory carcinoma of breast (SCB) typically harbours ETV6-NTRK3 gene fusion. Pan-Trk immunohistochemistry analysis (IHC) has been shown to be sensitive for SCB diagnosis. However, weak focal pan-Trk nuclear staining was previously found in 10% of non-secretory breast carcinomas. To further examine pan-Trk IHC specificity, we evaluated pan-Trk...

Alternative Titles

Full title

Nuclear staining for pan-Trk by immunohistochemistry is highly specific for secretory carcinoma of breast: pan-Trk in various subtypes of breast carcinoma

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2852631886

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2852631886

Other Identifiers

ISSN

0021-9746,1472-4146

E-ISSN

1472-4146

DOI

10.1136/jcp-2023-208989

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