Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase...
Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial
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Author / Creator
Umemura, Yoshie, MD , Orringer, Daniel, MD , Junck, Larry, Prof , Varela, Maria L, PhD , West, Molly E J, MS , Faisal, Syed M, PhD , Comba, Andrea, PhD , Heth, Jason, Prof , Sagher, Oren, Prof , Leung, Denise, MD , Mammoser, Aaron, MD , Hervey-Jumper, Shawn, MD , Zamler, Daniel, BS , Yadav, Viveka N, PhD , Dunn, Patrick, BS , Al-Holou, Wajd, MD , Hollon, Todd, MD , Kim, Michelle M, MD , Wahl, Daniel R, MD , Camelo-Piragua, Sandra, Prof , Lieberman, Andrew P, Prof , Venneti, Sriram, MD , McKeever, Paul, Prof , Lawrence, Theodore, Prof , Kurokawa, Ryo, MD , Sagher, Karen, BS , Altshuler, David, MD , Zhao, Lili, PhD , Muraszko, Karin, Prof , Castro, Maria G, Prof and Lowenstein, Pedro R, Prof
Publisher
England: Elsevier Ltd
Journal title
Language
English
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Publication information
Publisher
England: Elsevier Ltd
Subjects
More information
Scope and Contents
Contents
SummaryBackgroundHigh-grade gliomas have a poor prognosis and do not respond well to treatment. Effective cancer immune responses depend on functional immune cells, which are typically absent from the brain. This study aimed to evaluate the safety and activity of two adenoviral vectors expressing HSV1-TK (Ad-hCMV-TK) and Flt3L (Ad-hCMV-Flt3L) in pa...
Alternative Titles
Full title
Combined cytotoxic and immune-stimulatory gene therapy for primary adult high-grade glioma: a phase 1, first-in-human trial
Authors, Artists and Contributors
Author / Creator
Orringer, Daniel, MD
Junck, Larry, Prof
Varela, Maria L, PhD
West, Molly E J, MS
Faisal, Syed M, PhD
Comba, Andrea, PhD
Heth, Jason, Prof
Sagher, Oren, Prof
Leung, Denise, MD
Mammoser, Aaron, MD
Hervey-Jumper, Shawn, MD
Zamler, Daniel, BS
Yadav, Viveka N, PhD
Dunn, Patrick, BS
Al-Holou, Wajd, MD
Hollon, Todd, MD
Kim, Michelle M, MD
Wahl, Daniel R, MD
Camelo-Piragua, Sandra, Prof
Lieberman, Andrew P, Prof
Venneti, Sriram, MD
McKeever, Paul, Prof
Lawrence, Theodore, Prof
Kurokawa, Ryo, MD
Sagher, Karen, BS
Altshuler, David, MD
Zhao, Lili, PhD
Muraszko, Karin, Prof
Castro, Maria G, Prof
Lowenstein, Pedro R, Prof
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2860407461
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2860407461
Other Identifiers
ISSN
1470-2045,1474-5488
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(23)00347-9
