In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity
In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Chimeric antigen receptor T (CAR T) cell immunotherapy is successful at treating many cancers. However, it often induces life-threatening cytokine release syndrome (CRS) and neurotoxicity. Here, we show that in situ conjugation of polyethylene glycol (PEG) to the surface of CAR T cells (‘PEGylation’) creates a polymeric spacer that blocks cell-to-c...
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In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity
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TN_cdi_proquest_miscellaneous_2864157006
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2864157006
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ISSN
1476-1122
E-ISSN
1476-4660
DOI
10.1038/s41563-023-01646-6
