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Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome

Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2864899214

Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome

About this item

Full title

Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2023-10, Vol.622 (7981), p.188-194

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Inflammasome sensors detect pathogen- and danger-associated molecular patterns and promote inflammation and pyroptosis
1
. NLRP1 was the first inflammasome sensor to be described, and its hyperactivation is linked to autoinflammatory disease and cancer
2

6
. However, the mechanism underlying the activation and regulation of NLRP...

Alternative Titles

Full title

Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2864899214

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2864899214

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-023-06532-4

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