Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome
Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Inflammasome sensors detect pathogen- and danger-associated molecular patterns and promote inflammation and pyroptosis
1
. NLRP1 was the first inflammasome sensor to be described, and its hyperactivation is linked to autoinflammatory disease and cancer
2
–
6
. However, the mechanism underlying the activation and regulation of NLRP...
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Full title
Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome
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TN_cdi_proquest_miscellaneous_2864899214
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2864899214
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-023-06532-4