Preferential expression of SCN1A in GABAergic neurons improves survival and epileptic phenotype in a...
Preferential expression of SCN1A in GABAergic neurons improves survival and epileptic phenotype in a mouse model of Dravet syndrome
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Author / Creator
Ricobaraza, Ana , Bunuales, Maria , Gonzalez-Aparicio, Manuela , Fadila, Saja , Rubinstein, Moran , Vides-Urrestarazu, Irene , Banderas, Julliana , Sola-Sevilla, Noemi , Sanchez-Carpintero, Rocio , Lanciego, Jose Luis , Roda, Elvira , Honrubia, Adriana , Arnaiz, Patricia and Hernandez-Alcoceba, Ruben
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
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Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
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Scope and Contents
Contents
The
SCN1A
gene encodes the alpha subunit of a voltage-gated sodium channel (Na
v
1.1), which is essential for the function of inhibitory neurons in the brain. Mutations in this gene cause severe encephalopathies such as Dravet syndrome (DS). Upregulation of
SCN1A
expression by different approaches has demonstrated promising therap...
Alternative Titles
Full title
Preferential expression of SCN1A in GABAergic neurons improves survival and epileptic phenotype in a mouse model of Dravet syndrome
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Record Identifier
TN_cdi_proquest_miscellaneous_2876635457
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2876635457
Other Identifiers
ISSN
0946-2716
E-ISSN
1432-1440
DOI
10.1007/s00109-023-02383-8
