Leishmania genetic exchange is mediated by IgM natural antibodies
Leishmania genetic exchange is mediated by IgM natural antibodies
About this item
Full title
Author / Creator
Serafim, Tiago D. , Iniguez, Eva , Barletta, Ana Beatriz F. , Cecilio, Pedro , Doehl, Johannes S. P. , Short, Mara , Lack, Justin , Nair, Vinod , Disotuar, Maria , Wilson, Timothy , Coutinho-Abreu, Iliano V. , Meneses, Claudio , Andersen, John , Alves E Silva, Thiago Luiz , Oliveira, Fabiano , Vega-Rodriguez, Joel , Barillas-Mury, Carolina , Ribeiro, José M. C. , Beverley, Stephen M. , Kamhawi, Shaden and Valenzuela, Jesus G.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Host factors that mediate
Leishmania
genetic exchange are not well defined. Here we demonstrate that natural IgM (IgMn)
1
–
4
antibodies mediate parasite genetic exchange by inducing the transient formation of a spherical parasite clump that promotes parasite fusion and hybrid formation. We establish that IgMn from
Leishmania
Alternative Titles
Full title
Leishmania genetic exchange is mediated by IgM natural antibodies
Authors, Artists and Contributors
Author / Creator
Iniguez, Eva
Barletta, Ana Beatriz F.
Cecilio, Pedro
Doehl, Johannes S. P.
Short, Mara
Lack, Justin
Nair, Vinod
Disotuar, Maria
Wilson, Timothy
Coutinho-Abreu, Iliano V.
Meneses, Claudio
Andersen, John
Alves E Silva, Thiago Luiz
Oliveira, Fabiano
Vega-Rodriguez, Joel
Barillas-Mury, Carolina
Ribeiro, José M. C.
Beverley, Stephen M.
Kamhawi, Shaden
Valenzuela, Jesus G.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2882322998
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2882322998
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-023-06655-8
