PD-L1 and HIF-2α Upregulation in Head and Neck Paragangliomas after Embolization
PD-L1 and HIF-2α Upregulation in Head and Neck Paragangliomas after Embolization
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Author / Creator
Fischer, Alessa , Maccio, Umberto , Wang, Katharina , Friemel, Juliane , Broglie Daeppen, Martina A. , Vetter, Diana , Lehmann, Kuno , Reul, Astrid , Robledo, Mercedes , Hantel, Constanze , Bechmann, Nicole , Pacak, Karel , Zitzmann, Kathrin , Auernhammer, Christoph J. , Grossman, Ashley B. , Beuschlein, Felix and Nölting, Svenja
Publisher
Basel: MDPI AG
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Language
English
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Publisher
Basel: MDPI AG
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Scope and Contents
Contents
Hypoxia activates pathways associated with tumor progression, metastatic spread, and alterations in the immune microenvironment leading to an immunosuppressive phenotype. In particular, the upregulation of PD-L1, a target for therapy with checkpoint inhibitors, is well-studied in several tumors. However, the relationship between hypoxia and PD-L1 r...
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Full title
PD-L1 and HIF-2α Upregulation in Head and Neck Paragangliomas after Embolization
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TN_cdi_proquest_miscellaneous_2889999525
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2889999525
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ISSN
2072-6694
E-ISSN
2072-6694
DOI
10.3390/cancers15215199
